Research Programs

 

The Cardiovascular Research Institute embraces an inclusive, integrated and multi-disciplinary approach to research in cardiovascular science. The Institute includes scientists from a variety of disciplines including: molecular biology, physiology, biochemistry, molecular genetics, psychology, cell biology, medicine, biostatistics and epidemiology. Research programs in the Institute include:

 

 

Basic Science Programs

-The analysis of gene expression profiles in vascular cells using DNA microarray technology to elucidate gene regulatory networks determining vascular cell biology.

-The regulation of vascular cell fate and vessel structure by Notch signaling pathways.

-The physiologic genomics of salt-sensitive hypertension.

-The role of ID protein proteins as modulators of vascular cell gene transcription as critical determinants of vascular cell fate and vessel structure.

-The molecular basis of vascular remodeling and the relative roles of cell proliferation versus apoptosis.

-The role of nuclear receptors such as PPAR-g and PPAR-d as determinants of vascular function/structure.

-The molecular basis of obesity-related vascular disease.

-The molecular basis of diabetic vasculopathy.

-The role of vasoactive factors as determinants of vascular physiology and cell biology

-The molecular basis of hypertrophic cardiomyopathy.

-The mechanisms governing the intrinsic capacity of the heart to resist ischemic injury.

-The vascular biology of stroke susceptibility in the context of obesity and hypertension.

 

 

Clinical Science Programs

-The development of innovative clinical approaches and discovery of novel biomarkers to identify high risk patients and more effectively treat their cardiovascular disease.

-The discovery of novel ethnic-specific DNA polymorphisms that may promote the genetic susceptibility to diabetes and hypertension.

-The characterization of vascular physiology in humans at risk for cardiovascular complications such as myocardial infarction and stroke.

-The role of genetic factors as determinants of vascular function and structure in patients at risk for cardiovascular complications such as myocardial infarction and stroke.

-The enhancement of clinical interventions designed to prevent stroke and myocardial infarction in high-risk ethnic populations.

 

 

Population Science Programs

-The role of psychosocial stress and racism as a determinant of cardiovascular outcomes in ethnic populations.

-The influence of social factors as determinants of ethnic disparities in cardiovascular disease.

-The characterization of geographic and ethnic differences in cardiovascular disease/stroke risk factors in urban versus rural settings.

-To define the utility of vascular physiologic assays and novel biomarkers to identify high-risk subjects predisposed to myocardial infarction and stroke in community-based settings.

-The genetic epidemiology of cardiovascular disease and stroke in ethnic populations.

-The development of novel, culturally-sensitive intervention strategies to reduce the overall risk of cardiovascular disease in ethnic communities.

-The implementation of strategies designed to enhance the capacity of individuals within ethnic communities to achieve higher standards of cardiovascular health